Iba1

Iba1

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Description: Ionized calcium-binding adapter molecule 1 (Iba1) is a 147-amino acid calcium-binding protein involved in the rearrangement of the actin cytoskeleton during cell movement and phagocytosis1. Iba1 is a commonly used marker for microglial cells and due to being expressed in almost all sub-populations of cells of monocyte/macrophage lineage has been recognized as a pan-macrophage marker2. Iba1 has been shown to be a useful marker of cells of the monocyte/macrophage lineage in canine and feline inflammatory, proliferative and neoplastic disorders and for the differentiation between histiocytic tumors and other round cell tumor and melanomas3,4,5.

 

Catalog: VeteMAbXXX

Species Reactivity: 

Source: 

Clone:

Antigen: Iba1

Positive Control: Normal brain

 

References

    1. Ohsawa K., Imai Y., Kanazawa H., Sasaki Y. and Kohasaka, S. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J Cell Sci. 2000;113(17):3073-3084. [PMID 10934045]
    2. Kohler, C. Allograft inflammatory factor-1/ionized calcium-binding adapter molecule 1 is specficially expressed by most subpopulations of macrophages and spermatids in testis. Cell Tissue Res. 2007;330(2):291-302. [PMID 17874251]
    3. Ide, T., Uchida, K., Kadawa, Y., Suzuki, K. and Nakayama, H. Pathological and immunohistochemical features of subdural histiocytic sarcomas in 15 dogs. J Clin Periodontol. 2003;30(1):14-18. [PMID 12702106]
    4. Ide, T., Uchida, K., Tamura, S. and Nakayama, H. Histocytic sarcoma in the brain of a cat. J Vet Med Sci;72(1):99-102. [PMID 19915332]
    5. Pierezan, F., Mansell, J., Ambrus, A. and Rodrigues Hoffman, A. Immunohistochemical Expression of Ionized Calcium Binding Adapter Molecule 1 in Cutaneous Histiocytic Proliferative, Neoplastic and Inflammatory Disorder of Dogs and Cats. J. Comp. Path. 2014;151(4):347-351. [PMID 25172051]